Acalabrutinib Impurity 20 CAS CATO-C4X-305520
| CAS No. | CATO-C4X-305520 |
| Molecular Formula | C21H19N5O3 |
| Molecular Weight | 389.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Acalabrutinib Impurity 20 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Acalabrutinib Impurity 20 (CAS CATO-C4X-305520, C21H19N5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Acalabrutinib Impurity 20 (C21H19N5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H19N5O3 |
| Molecular Weight | 389.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 15 (CAS CATO-C4X-305515)
- Acalabrutinib Impurity 10 (CAS CATO-C4X-305510)
- Acalabrutinib Impurity 12 (CAS CATO-C4X-305512)
- Acalabrutinib Impurity 5 (CAS CATO-C4X-30555)
- Acalabrutinib Impurity 16 (CAS 2230757-50-1)
- Acalabrutinib Impurity 2 (CAS CATO-C4X-30552)
- Acalabrutinib Impurity 3 (CAS CATO-C4X-30553)
- Acalabrutinib Impurity 4 (CAS 2198380-46-8)
Recommended Standards
- Thiotepa Impurity 11 (CAS CATO-C4X-215611)
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- Terbinafine Impurity 37 (CAS CATO-C4X-133837)
- Salbutamol Impurity 138 Trifluoroacetic Acid (CAS CATO-C4X-1176138)
- Amisulpride Impurity 20 (CAS CATO-C4X-104520)
- 4-Ethyl-1,3-dioxolan-2-one (CAS 4437-85-8)
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- 5-Chloro-2-cyclopropyl-1H-imidazo[4,5-b]pyridine (CAS 146014-81-5)
- (R)-N-Methyl-N-(pyrrolidin-3-yl)pyrazin-2-amine hydrochloride (CAS 1417789-29-7)
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- Ethyl (Z)-2-cyano-3-[3-(4-fluorophenyl)-2,1-benzisoxazol-5-yl]-2-propenoate (CAS 685107-62-4)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com