Acalabrutinib Impurity 11 CAS CATO-C4X-305511
| CAS No. | CATO-C4X-305511 |
| Molecular Formula | C17H17N5O2 |
| Molecular Weight | 323.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 323.35 g/mol gives Acalabrutinib Impurity 11 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Acalabrutinib Impurity 11 (CAS CATO-C4X-305511) is a certified pharmaceutical impurity reference standard with the molecular formula C17H17N5O2 and a molecular weight of 323.35 g/mol.
Acalabrutinib Impurity 11 (C17H17N5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Acalabrutinib Impurity 11 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H17N5O2 |
| Molecular Weight | 323.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 30 (CAS CATO-C4X-305530)
- Acalabrutinib Impurity 8 (CAS CATO-C4X-30558)
- Acalabrutinib Impurity 24 (CAS 2097352-14-0)
- Acalabrutinib Impurity 31 (CAS CATO-C4X-305531)
- Acalabrutinib Impurity 7 (CAS CATO-C4X-30557)
- Acalabrutinib Impurity 6 (CAS CATO-C4X-30556)
- Acalabrutinib Impurity 5 (CAS CATO-C4X-30555)
- Acalabrutinib Impurity 25 (CAS CATO-C4X-305525)
Recommended Standards
- Belumosudil Impurity 41 (CAS CATO-C4X-298841)
- 2-[2-Hydroxy-5-[2-(methacryloyloxy)ethyl]phenyl]-2H-benzotriazole (CAS 96478-09-0)
- Finerenone Impurity 219 (CAS CATO-C4X-2880219)
- Fmoc-α-Me-D-Ser-lactone (CAS 1926163-89-4)
- Nebivolol Impurity 2 (CAS CATO-C4X-19682)
- Rotigotine Impurity 32 (CAS CATO-C4X-192732)
- Nintedanib impurity 78 (CAS CATO-C4X-181478)
- 5-(P-tolyl)furan-2-carboxylic acid (CAS 52938-98-4)
- (4-Methyl-6-(1H-pyrrol-1-yl)pyridin-3-yl)boronic acid (CAS 858523-54-3)
- Ethyl 3-amino-4-chloro-2-methylbenzoate (CAS 157652-34-1)
- Tripropylamine (CAS 102-69-2)
- n-Isopropyl-3-(1-methyl-1h-tetrazol-5-yl)aniline (CAS 1153008-15-1)
- 4-Difluoromethyl-pyrimidine-5-carboxylic acid ethyl ester (CAS 1600338-90-6)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
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