Acalabrutinib Impurity 5 CAS CATO-C4X-30555
| CAS No. | CATO-C4X-30555 |
| Molecular Formula | C17H18BrN5 |
| Molecular Weight | 372.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Acalabrutinib Impurity 5 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Acalabrutinib Impurity 5 (CAS CATO-C4X-30555, C17H18BrN5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H18BrN5, Acalabrutinib Impurity 5 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 372.26 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18BrN5 |
| Molecular Weight | 372.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 20 (CAS CATO-C4X-305520)
- Acalabrutinib Impurity 31 (CAS CATO-C4X-305531)
- Acalabrutinib Impurity 15 (CAS CATO-C4X-305515)
- Acalabrutinib Impurity 24 (CAS 2097352-14-0)
- Acalabrutinib Impurity 10 (CAS CATO-C4X-305510)
- Acalabrutinib Impurity 12 (CAS CATO-C4X-305512)
- Acalabrutinib Impurity 30 (CAS CATO-C4X-305530)
- Acalabrutinib Impurity 16 (CAS 2230757-50-1)
Recommended Standards
- Anastrozole Impurity 21 (CAS CATO-C4X-123921)
- Allyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (CAS 1073354-49-0)
- Netupitant Impurity 45 (CAS 1648578-86-2)
- [4-(4,6-Dichloropyrimidin-2-ylsulfanyl)phenyl]carbamic acid tert-butyl ester (CAS 1215081-83-6)
- Lenvatinib Impurity 56 (CAS CATO-C4X-114056)
- Docetaxel Impurity 76 (CAS CATO-C4X-161976)
- Salbutamol Impurity 85 (CAS 115787-52-5（free base）)
- azocane (CAS 1121-92-2)
- Dichloro(η6-p-cymene)ruthenium (CAS 100928-22-1)
- 6-(Trifluoromethoxy)-1H-indazol-5-amine (CAS 1499162-39-8)
- 3-(4-Ethoxy-3-methoxyphenyl)prop-2-en-1-amine (CAS 1344865-76-4)
- Poly(N-vinyl caprolactam) (CAS 25189-83-7)
- 7-(Hydroxymethyl)-1H-pyrido[3,4-b][1,4]oxazin-2(3H)-one (CAS 615568-79-1)
- Semaglutide Impurity 158 (x TFA Salt) (CAS CATO-C4X-2226158)
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