Ruxolitinib Impurity 3 CAS 2102675-40-9
| CAS No. | 2102675-40-9 |
| Molecular Formula | C17H19N5O2 |
| Molecular Weight | 325.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 325.37 g/mol gives Ruxolitinib Impurity 3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ruxolitinib Impurity 3 (CAS 2102675-40-9, C17H19N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H19N5O2, Ruxolitinib Impurity 3 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 325.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ruxolitinib Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H19N5O2 |
| Molecular Weight | 325.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 5 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 169 (CAS CATO-C4X-2058169)
- Ruxolitinib Impurity 77 (CAS 3016399-21-3)
- Ruxolitinib Impurity 1 (CAS 2606144-44-7)
- Ruxolitinib Impurity 170 (CAS CATO-C4X-2058170)
- Ruxolitinib Impurity 2 (CAS 2102675-42-1)
- Ruxolitinib Impurity 27 (CAS CATO-C4X-205827)
- Ruxolitinib Impurity 6 (CAS 1911644-32-0)
- Ruxolitinib Impurity 128 (CAS CATO-C4X-2058128)
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