Ruxolitinib Impurity 1 CAS 2606144-44-7
| CAS No. | 2606144-44-7 |
| Molecular Formula | C16H18N6O2 |
| Molecular Weight | 326.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Ruxolitinib Impurity 1 (CAS 2606144-44-7) is a certified pharmaceutical impurity reference standard with the molecular formula C16H18N6O2 and a molecular weight of 326.35 g/mol.
Based on its molecular formula C16H18N6O2, Ruxolitinib Impurity 1 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 326.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Ruxolitinib Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H18N6O2 |
| Molecular Weight | 326.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 6 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 169 (CAS CATO-C4X-2058169)
- Ruxolitinib Impurity 3 (CAS 2102675-40-9)
- Ruxolitinib Impurity 77 (CAS 3016399-21-3)
- Ruxolitinib Impurity 170 (CAS CATO-C4X-2058170)
- Ruxolitinib Impurity 2 (CAS 2102675-42-1)
- Ruxolitinib Impurity 27 (CAS CATO-C4X-205827)
- Ruxolitinib Impurity 6 (CAS 1911644-32-0)
- Ruxolitinib Impurity 128 (CAS CATO-C4X-2058128)
Recommended Standards
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- n-Propyl-2-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide (CAS 155329-60-5)
- Isomultiflorenol (CAS 24462-48-4)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com