Difamilast Impurity 5 CAS 2103190-81-2
| CAS No. | 2103190-81-2 |
| Molecular Formula | C21H20F2N2O6 |
| Molecular Weight | 434.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Difamilast Impurity 5 (C21H20F2N2O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 434.39 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Difamilast Impurity 5 (CAS 2103190-81-2, C21H20F2N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H20F2N2O6 |
| Molecular Weight | 434.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difamilast Standards
- Difamilast Impurity 8 (CAS 2103190-85-6)
- Difamilast Impurity 3 (CAS 937782-02-0)
- Difamilast Impurity 1 (CAS 1574285-40-7)
- Difamilast (CAS 937782-05-3)
- Difamilast Impurity 10 (CAS 2103190-58-3)
- Difamilast Impurity 6 (CAS 937782-01-9)
- Difamilast Impurity 2 (CAS 2103190-94-7)
- Difamilast Impurity 4 (CAS 2103190-65-2)
Recommended Standards
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- 4-(4-Chloro-2-methylphenyl)piperidine (CAS 262272-25-3)
- N-[(1-Boc-4-piperidyl)methyl]pyrimidin-2-amine (CAS 1420889-45-7)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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