Regorafenib EP Impurity B CAS 2141961-84-2
| CAS No. | 2141961-84-2 |
| Molecular Formula | C15H14FN3O3 |
| Molecular Weight | 303.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Regorafenib EP Impurity B (CAS 2141961-84-2, C15H14FN3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Regorafenib EP Impurity B is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 303.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14FN3O3 |
| Molecular Weight | 303.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Regorafenib Standards
- Regorafenib EP Impurity B (CAS CATO-C4X-10478)
- Regorafenib Impurity 22 (CAS CATO-C4X-104722)
- Regorafenib Impurity 80 (CAS CATO-C4X-104780)
- Regorafenib Impurity 33 (CAS CATO-C4X-104733)
- Regorafenib Impurity 34 (CAS CATO-C4X-104734)
- Regorafenib Impurity 71 (CAS CATO-C4X-104771)
- Regorafenib Impurity 21 (CAS 35592-96-2)
- Regorafenib Impurity 63 (CAS CATO-C4X-104763)
Recommended Standards
- 4-(1,3-Dioxoisoindolin-2-yl)benzenesulfonic acid (CAS 86581-47-7)
- 4-(diphenylphosphoryl)benzonitrile (CAS 5032-54-2)
- 3-Amino-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid (CAS 6313-47-9)
- 5-Nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 937012-11-8)
- Biapenem Impurity 22 (CAS CATO-C4X-227322)
- Oseltamivir Impurity 124 (CAS CATO-C4X-1720124)
- Fasudil impurity 66 (CAS CATO-C4X-136566)
- (R)-2-Amino-3-(2,4-difluorophenyl)propanoic acid (CAS 266360-60-5)
- 2-Amino-N-cyclopropyl-N-(pyridin-4-ylmethyl)acetamide (CAS 1184746-03-9)
- 5-(3-fluorophenyl)-2,3-dihydro-1H-indole hydrochloride (CAS 1354959-99-1)
- 2-Chloro-5-fluoroquinazolin-4-amine (CAS 1107695-00-0)
- 2,3,5,6-Tetramethylphenylmagnesium bromide, 0.5M THF (CAS 75724-98-0)
- 1-Ethyl-4-((4-propylphenyl)ethynyl)benzene (CAS 102225-55-8)
- Tyr-Proinsulin C-Peptide (55-89) (human) (CAS 139532-11-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com