Regorafenib Impurity 22 CAS CATO-C4X-104722
| CAS No. | CATO-C4X-104722 |
| Molecular Formula | C13H11ClFN3O2 |
| Molecular Weight | 295.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Regorafenib Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Regorafenib Impurity 22 (CAS CATO-C4X-104722) is a certified pharmaceutical impurity reference standard with the molecular formula C13H11ClFN3O2 and a molecular weight of 295.70 g/mol.
Based on its molecular formula C13H11ClFN3O2, Regorafenib Impurity 22 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 295.70 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H11ClFN3O2 |
| Molecular Weight | 295.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Regorafenib Standards
- Regorafenib Impurity 80 (CAS CATO-C4X-104780)
- Regorafenib Impurity 33 (CAS CATO-C4X-104733)
- Regorafenib Impurity 34 (CAS CATO-C4X-104734)
- Regorafenib EP Impurity B (CAS 2141961-84-2)
- Regorafenib EP Impurity B (CAS CATO-C4X-10478)
- Regorafenib Impurity 71 (CAS CATO-C4X-104771)
- Regorafenib Impurity 21 (CAS 35592-96-2)
- Regorafenib Impurity 63 (CAS CATO-C4X-104763)
Recommended Standards
- 6-(4-Chlorophenoxy)-5-nitroimidazo[2,1-b][1,3]thiazole (CAS 339008-06-9)
- 6-(3-Chlorophenoxy)-5-nitroimidazo[2,1-b][1,3]thiazole (CAS 339008-09-2)
- Alogliptin Impurity 67 (CAS 865759-24-6)
- 6-(2-Chlorophenoxy)-5-nitroimidazo[2,1-b]thiazole (CAS 339008-07-0)
- Beclometasone Dipropionate Monohydrate EP Impurity F (CAS 887130-69-0)
- Chloropyramine Impurity 8 (CAS CATO-C4X-30368)
- Vancomycin EP Impurity C (CAS 82198-76-3)
- Methyl 2,4,6-trimethylbenzoate (CAS 2282-84-0)
- 1-(3-Aminopropyl)pyrrolidin-3-ol (CAS 99709-62-3)
- Tert-butyl (R)-((3-fluoropyrrolidin-3-yl)methyl)carbamate (CAS 2165900-52-5)
- 4,4,5,5-Tetramethyl-2-(2-methyl-4-nitrophenyl)-1,3,2-dioxaborolane (CAS 883715-40-0)
- Crizotinib Impurity 9 (CAS 1448326-33-7)
- 2-{4-oxo-7-phenyl-3H,4H-thieno[3,2-d]pyrimidin-3-yl}-N-(4-phenoxyphenyl)acetamide (CAS 1105224-22-3)
- Polymyxin B nonapeptide TFA (CAS 2220175-42-6)
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