Regorafenib Impurity 33 CAS CATO-C4X-104733
| CAS No. | CATO-C4X-104733 |
| Molecular Formula | C13H10FN3O4 |
| Molecular Weight | 291.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 291.23 g/mol gives Regorafenib Impurity 33 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Regorafenib Impurity 33 (CAS CATO-C4X-104733), a pharmacopoeial impurity reference standard (molecular formula C13H10FN3O4, MW 291.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Regorafenib Impurity 33 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 291.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10FN3O4 |
| Molecular Weight | 291.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Regorafenib Standards
- Regorafenib Impurity 34 (CAS CATO-C4X-104734)
- Regorafenib Impurity 22 (CAS CATO-C4X-104722)
- Regorafenib Impurity 80 (CAS CATO-C4X-104780)
- Regorafenib EP Impurity B (CAS 2141961-84-2)
- Regorafenib EP Impurity B (CAS CATO-C4X-10478)
- Regorafenib Impurity 71 (CAS CATO-C4X-104771)
- Regorafenib Impurity 21 (CAS 35592-96-2)
- Regorafenib Impurity 63 (CAS CATO-C4X-104763)
Recommended Standards
- Ths-044 (CAS 62054-67-5)
- Ethyl 7-hydroxy-2-methyl-7-(trifluoromethyl)-4h,7h-pyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 923232-09-1)
- Bumetanide Impurity 42 (CAS 320417-11-6)
- Ethyl (Z)-3-[(3-methyl-1H-pyrazol-5-yl)amino]-2-(2,2,2-trifluoroacetyl)-2-propenoate (CAS 477709-41-4)
- Selexipag Impurity 35 (CAS CATO-C4X-196135)
- Mosapride Impurity 22 (CAS CATO-C4X-104422)
- Piperacillin Impurity 28 (CAS CATO-C4X-173228)
- 5-((4-Chlorophenyl)amino)-6-hydroxy-2-(methylthio)pyrimidin-4(3H)-one (CAS 6630-69-9)
- Ethyl 5-amino-4-bromo-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (CAS 1427011-68-4)
- 1-(Tert-butyl) 2-methyl (2S,4S)-4-(dimethylamino)pyrrolidine-1,2-dicarboxylate (CAS 149152-71-6)
- 3-Bromo-4-[(4-methylpiperazin-1-yl)methyl]aniline (CAS 859027-13-7)
- Methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (CAS 1334312-52-5)
- 2-(3-Ethylazetidin-1-yl)acetic acid (CAS 1530906-31-0)
- Allo-D-Ile27-Tirzepatide (CAS CATO-CPTD788961)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com