Apremilast Impurity 4 CAS 2201974-01-6
| CAS No. | 2201974-01-6 |
| Molecular Formula | C22H24N2O7S |
| Molecular Weight | 460.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Apremilast Impurity 4 is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Apremilast Impurity 4 (CAS 2201974-01-6, C22H24N2O7S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Apremilast Impurity 4 (C22H24N2O7S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 460.50 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Apremilast Impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O7S |
| Molecular Weight | 460.50 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Apremilast Standards
Recommended Standards
- Fmoc-Dab(Z)-OH (CAS 252049-08-4)
- 1,3-Bis(4-fluorophenyl)-4,7-diphenyl-4,7-dihydroisobenzofuran (CAS 132980-69-9)
- 1-(Benzo[d][1,3]dioxol-5-yl)-2-((4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethanone (CAS 618432-46-5)
- Methyl 2-{[6-(4-methylphenoxy)-2-phenylpyrimidin-4-yl]sulfonyl}benzoate (CAS 478067-37-7)
- Lobeline impurity 7 HCl (CAS CATO-C4X-18187)
- Etelcalcetide Impurity 44 (CAS CATO-C4X-324744)
- Ketotifen Impurity 22 (CAS 4506-53-0)
- Rhodium trifluoropentanedionate (CAS 67145-51-1)
- 7-(Aminomethyl)-3,4-dihydroquinolin-2(1H)-one (CAS 916303-79-2)
- (1S,3S,5S,6R,8S)-3-Ethyl-5-(6-methoxyquinolin-4-yl)-4-oxa-1-azatricyclo[4.4.0.03,8]decane (CAS 205495-11-0)
- Dimethyl (S)-2-methylsuccinate (CAS 63163-08-6)
- 5-Ethyl-[1,3]dithiolo[4,5-b]pyrazin-2-one (CAS 80458-32-8)
- 7-(3-Methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol (CAS 865546-58-3)
- Semaglutide impurity 77 (CAS CATO-C4X-222677)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com