Macitentan Impurity N1 CAS 2443747-63-3
| CAS No. | 2443747-63-3 |
| Molecular Formula | C19H20BrClN6O4S |
| Molecular Weight | 543.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 543.82 g/mol gives Macitentan Impurity N1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Macitentan Impurity N1 (CAS 2443747-63-3) is a certified pharmaceutical impurity reference standard with the molecular formula C19H20BrClN6O4S and a molecular weight of 543.82 g/mol.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, Macitentan Impurity N1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 543.82 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Macitentan Impurity N1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H20BrClN6O4S |
| Molecular Weight | 543.82 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 35 (CAS 441798-36-3)
- Macitentan Impurity 8 (CAS 556796-88-4)
- Macitentan Impurity 3 (CAS 1103522-45-7)
- Macitentan Impurity 55 (CAS CATO-C4X-117555)
- Macitentan Impurity 1 (CAS 441798-25-0)
- Macitentan Impurity 2 (CAS 441796-13-0)
- Macitentan Impurity 16 (CAS 2211059-00-4)
- Macitentan Impurity 56 (CAS CATO-C4X-117556)
Recommended Standards
- 4-(9,9-Dioctyl-7-phenyl-9H-fluoren-2-yl)pyridine (CAS 811460-27-2)
- Aminocaproic Nitrilotriacetic Acid Tri-t-Butyl Ester (CAS 1218921-96-0)
- N-(2-Bromo-4-methylphenyl)-2-((4-(4-chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 476484-44-3)
- (S,R,S)-AHPC-C5-NH2 (CAS 2170695-19-7)
- Nimodipine Impurity 18 (CAS CATO-C4X-138518)
- Lotilaner Impurity 21 (CAS CATO-C4X-325621)
- Lapatinib Impurity 32 (p-Toluenesulfonic acid) (CAS CATO-C4X-119132)
- (2,5-Difluoro-4-isopropoxyphenyl)methanol (CAS 2121514-71-2)
- 8-Methoxy-4-methyl-6-nitroquinolin-2(1H)-one (CAS 50553-66-7)
- 5-Methyl-5-[4-(trifluoromethyl)phenyl]imidazolidine-2,4-dione (CAS 868635-03-4)
- Diethyl 2-(azetidin-3-yl)malonate (CAS 2167887-25-2)
- 6-Chloro-3-(chloromethyl)pyrazin-2-amine (CAS 1393541-28-0)
- 2-(Chloromethyl)-4-(difluoromethyl)-5-(trifluoromethoxy)pyridine-3-carboxylic acid (CAS 1805953-48-3)
- Semaglutide impurity 63 (CAS CATO-C4X-222663)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com