Hydrocortisone 21-Hemisuccinate CAS 2203-97-6
| CAS No. | 2203-97-6 |
| Molecular Formula | C25H34O8 |
| Molecular Weight | 462.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Hydrocortisone 21-Hemisuccinate.
Hydrocortisone 21-Hemisuccinate (CAS 2203-97-6), molecular formula C25H34O8 and molecular weight 462.53 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Hydrocortisone 21-Hemisuccinate (C25H34O8) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H34O8 |
| Molecular Weight | 462.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Hydrocortisone Standards
- Hydrocortisone Impurity 32 (CAS 103242-89-3)
- Hydrocortisone Impurity 67 (CAS 146201-55-0)
- Hydrocortisone Impurity 75 (CAS 220489-73-6)
- Hydrocortisone Impurity 39 (CAS 3593-96-2)
- Hydrocortisone 17-Propionate 21-Acetate (CAS 74050-20-7)
- Hydrocortisone Impurity 01 (CAS 10215-75-5)
- Hydrocortisone impurity 40 (CAS 33767-18-9)
- Hydrocortisone Impurity 60 (CAS CATO-C4X-140160)
Recommended Standards
- 6-[N,N-Di(2-hydroxybenzyl)amino]-2-[(3-hydroxypropyl)amino]-9-isopropylpurine (CAS 1076200-04-8)
- 1132816-77-3 tert-Butyl 3-[1-methyl-3-(4-benzyl-2-oxo-1,3-oxazol-idin-3-yl)-3-oxopropyl]indole-1-carboxylate (CAS 1132816-77-3)
- 4-(4-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)aniline (CAS 1144068-84-7)
- Canagliflozin Impurity 87 (CAS CATO-C4X-112387)
- Rabeprazole sodium (CAS 117976-90-6)
- 1-Acetyl-2-methyl-D-proline (CAS 1268520-12-2)
- 6,7-Dichloro-4-(4-fluorophenyl)-2-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one (CAS 161716-26-3)
- Dimethyl 3-bromopyridine-2,6-dicarboxylate (CAS 316808-11-4)
- trans-Dichlorobis(glycine)palladium (CAS 79351-56-7)
- 3-(Benzylthio)azepan-2-one (CAS 88833-17-4)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-((4-pentylphenyl)sulfonyl)-1,4-diazepane (CAS 646456-06-6)
- Oxcarbazepine Impurity 20 (CAS 260-94-6)
- 6H-Furo[3,2-e]indole (CAS 19546-89-5)
- (Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt (CAS 179986-95-9)
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