Diclofenac sodium Impurity 56 CAS 221016-39-3
| CAS No. | 221016-39-3 |
| Molecular Formula | C17H17Cl2NO4 |
| Molecular Weight | 370.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Diclofenac sodium Impurity 56 (C17H17Cl2NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Diclofenac sodium Impurity 56 (CAS 221016-39-3), a pharmacopoeial impurity reference standard (molecular formula C17H17Cl2NO4, MW 370.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H17Cl2NO4 |
| Molecular Weight | 370.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac N-Oxydiethylamine Ester (CAS CATO-C4X-16142)
- Diclofenac EP Impurity D Sodium Salt (CAS 127792-45-4)
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Recommended Standards
- 4-(iodo(phenyl)methyl)-1,1'-biphenyl (CAS CATO-C3D-6177)
- Felodipine EP Impurity B (CAS 91189-59-2)
- N-(2-benzoyl-4-chlorophenyl)-2-chlorobenzamide (CAS 289059-82-1)
- Felodipine Impurity 11 (CAS 150131-21-8)
- Nicardipine Impurity 12 (CAS CATO-C4X-171012)
- Tinidazole Impurity 22 (CAS CATO-C4X-193022)
- Etrasimod Impurity 58 (CAS 380350-42-5)
- 4-bromo-5-(chlorosulfonyl)-2-methoxybenzoic acid (CAS 72135-35-4)
- (R)-N-Cyclopropylpyrrolidine-2-carboxamide (CAS 477575-02-3)
- 2-((4-Amino-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)-N-(benzo[d][1,3]dioxol-5-yl)acetamide (CAS 869068-36-0)
- 2-Methyl Nornicotine (CAS 64114-19-8)
- 5-Bromo-2,3-dihydro-1-benzofuran-7-carbaldehyde (CAS 281678-73-7)
- 2-(2-Chloro-3,4-dimethoxyphenyl)acetonitrile (CAS 7537-07-7)
- Dulaglutide (CAS 923950-08-7)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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