Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) CAS 2240-28-0

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.2240-28-0
Molecular FormulaC27H37FO6
Molecular Weight476.58 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) CAS 2240-28-0 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 476.58 g/mol gives Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) (CAS 2240-28-0), a pharmacopoeial impurity reference standard (molecular formula C27H37FO6, MW 476.58 g/mol) used for the identification and quantification of trace impurities in APIs.

Owing to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution, Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 476.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC27H37FO6
Molecular Weight476.58 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity97%+
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1957
Halogen ContentF-containing

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