Betamethasone Valerate EP Impurity C CAS 33755-46-3
| CAS No. | 33755-46-3 |
| Molecular Formula | C27H37FO6 |
| Molecular Weight | 476.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Betamethasone Valerate EP Impurity C (C27H37FO6) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 476.58 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Betamethasone Valerate EP Impurity C (CAS 33755-46-3, C27H37FO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Betamethasone Valerate EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H37FO6 |
| Molecular Weight | 476.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Cyclic 17,21-(Ethyl Orthopropionate) (CAS 1062-09-5)
- Betamethasone Impurity N82 (CAS 123013-29-6)
- Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) (CAS 2240-28-0)
- Betamethasone 17A-Valerate (CAS 2152-44-5)
- Betamethasone Acetate EP Impurity C (CAS 330157-05-6)
- Betamethasone Impurity 21 (CAS 154713-07-2)
- Betamethasone impurity 103 (CAS CATO-C4X-1437103)
- Betamethasone Impurity 132 (CAS CATO-C4X-1437132)
Recommended Standards
- 6-alpha-Methyl Prednisolone Aceponate-13C-d3 (CAS CATO-C4X-191971)
- Flumetasone Pivalate EP Impurity C (CAS 1926-94-9)
- Dexamethasone Impurity 121 (CAS 2600-31-9)
- N-(2-(Dimethylamino)ethyl)-4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)-N-methylbenzenesulfonamide (CAS 107478-35-3)
- Ulipristal Impurity 25 (CAS CATO-C4X-191525)
- Lidocaine Impurity 100 (CAS CATO-C4X-1679100)
- Relugolix Impurity 166 (CAS CATO-C4X-2429166)
- Methyl 6-{[2-(4-methylbenzenesulfonamido)phenyl]sulfanyl}pyridine-3-carboxylate (CAS 478033-23-7)
- 2-{[4-(4-methoxyphenyl)-5-(phenoxymethyl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid (CAS 893725-85-4)
- (2S)-2-Amino-3-(tetrahydrofuran-3-yl)propanoic acid (CAS 1344964-79-9)
- 6-Amino-5-(difluoromethyl)-3-methylpyridine-2-sulfonamide (CAS 1805145-29-2)
- Clobazam EP Impurity C (CAS 22316-16-1)
- 1-(5-Isopropyl-1H-pyrrol-3-yl)ethanone (CAS 16168-98-2)
- Macrocyclic Peptide flaviviridae Viruses InhibitorDISCONTINUED (CAS 1510841-23-2)
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