Flumetasone Pivalate EP Impurity C CAS 1926-94-9
| CAS No. | 1926-94-9 |
| Molecular Formula | C27H37FO6 |
| Molecular Weight | 476.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Flumetasone Pivalate EP Impurity C (CAS 1926-94-9) is a certified pharmaceutical impurity reference standard with the molecular formula C27H37FO6 and a molecular weight of 476.58 g/mol.
The molecular framework of Flumetasone Pivalate EP Impurity C (C27H37FO6) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flumetasone Pivalate EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H37FO6 |
| Molecular Weight | 476.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Flumetasone Standards
- Flumetasone Impurity 7 (CAS 61633-73-6)
- Flumetasone Impurity 8 (CAS CATO-C4X-19108)
- Flumetasone Impurity 14 (CAS 3873-19-6)
- Flumetasone Impurity 9 (CAS 2541-37-9)
- Flumetasone Impurity 16 (CAS CATO-C4X-191016)
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- Flumetasone Impurity 10 (CAS 382631-11-0)
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Recommended Standards
- Dexamethasone Impurity 121 (CAS 2600-31-9)
- Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate) (CAS 2240-28-0)
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- Betamethasone Valerate EP Impurity C (CAS 33755-46-3)
- Gefitinib Impurity 53 (CAS CATO-C4X-111753)
- Cefixime Impurity C17 (CAS 84080-68-2)
- Pazopanib Impurity 20 (CAS 3934-20-1)
- N-Hydroxyphenanthrene-9-carboximidamide (CAS 885966-97-2)
- 5-(2,4-Dichlorophenoxy)-3,6-diphenyl-1,2,4-triazine (CAS 339013-02-4)
- Azilsartan Impurity 23 (CAS 136285-65-9)
- tert-Butyl (3-aminospiro[3.3]heptan-1-yl)carbamate (CAS 1955556-81-6)
- Ethyl 5-amino-4-methyl-1H-pyrazole-3-carboxylate (CAS 1357795-98-2)
- (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-acetamidophenyl)propanoic acid (CAS 265321-34-4)
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