Atorvastatin Impurity 138 Calcium Salt CAS 2243639-98-5
| CAS No. | 2243639-98-5 |
| Molecular Formula | 2*C33H34FN2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Atorvastatin Impurity 138 Calcium Salt (CAS 2243639-98-5) is a certified pharmaceutical impurity reference standard with the molecular formula C33H34FN2O5Ca and a molecular weight of 597.72 g/mol.
The molecular framework of Atorvastatin Impurity 138 Calcium Salt (C33H34FN2O5Ca) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | 2*C33H34FN2O5 Ca |
| Molecular Weight | 597.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 22 (CAS 1035205-25-4)
- Atorvastatin Calcium Propylene Glycol Solvate (CAS 1040350-07-9)
- Atorvastatin Lactone Diepoxide (CAS 1046118-40-4)
- Atorvastatin Lactam calcium Salt Impurity (CAS 1046118-41-5)
- Atorvastatin Impurity 86 (CAS 1046118-44-8)
- Atorvastatin Impurity 141 Calcium Salt (CAS 1046378-58-8)
- Atorvastatin Impurity 76 (CAS 1099474-28-8)
- Atorvastatin EP Impurity F(Calcium Salt) (CAS 1105067-87-5)
Recommended Standards
- Imipenem Impurity 11 (CAS CATO-C4X-166211)
- Aminolevulinic Acid Impurity 8 (CAS CATO-C4X-21218)
- Regorafenib Impurity 35 (CAS CATO-C4X-104735)
- 5,10,15,20-Tetra (1-methyl-4-pyridyl) porphyrin copper (CAS 48242-70-2)
- 5-(2-Chloro-4-methanesulfonylphenyl)-1-(3,4-difluorophenyl)-1H-1,2,3,4-tetrazole (CAS 400089-25-0)
- 2-Fluoro-1-(trifluoromethyl)-3-vinylbenzene (CAS 1298094-29-7)
- 2-(2-((Benzyl(cyclopropyl)amino)methyl)pyrrolidin-1-yl)ethanol (CAS 1353976-19-8)
- tert-Butyl N-{[(3,4-difluorophenyl)carbamoyl]methyl}carbamate (CAS 1043391-03-2)
- Custom Semivolatile Mix 8 (CAS CATO-LCEM500797-AC)
- Acetyl-(Leu28·31)-Neuropeptide Y (24-36) (CAS 155709-24-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com