Clobetasone butyrate EP Impurity C CAS 639817-49-5

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.639817-49-5
Molecular FormulaC26H34ClFO5
Molecular Weight481.00 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Clobetasone butyrate EP Impurity C CAS 639817-49-5 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 481.00 g/mol gives Clobetasone butyrate EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Clobetasone butyrate EP Impurity C (CAS 639817-49-5) is a certified pharmaceutical impurity reference standard with the molecular formula C26H34ClFO5 and a molecular weight of 481.00 g/mol.

Structurally, Clobetasone butyrate EP Impurity C (C26H34ClFO5) contains a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 481.00 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Clobetasone butyrate EP Impurity C under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC26H34ClFO5
Molecular Weight481.00 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity≥95%
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1985
Halogen ContentF/Cl-containing

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