Furosemide Impurity N3 CAS 22893-13-6
| CAS No. | 22893-13-6 |
| Molecular Formula | C12H11ClN2O5S |
| Molecular Weight | 330.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Furosemide Impurity N3 (CAS 22893-13-6, C12H11ClN2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Furosemide Impurity N3 (C12H11ClN2O5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Furosemide Impurity N3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H11ClN2O5S |
| Molecular Weight | 330.74 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide (CAS 54-31-9)
- Furosemide EP Impurity A (CAS 4818-59-1)
- Furosemide Impurity 55 (CAS CATO-C4X-140255)
- Furosemide Amide Impurity (CAS 4793-47-9)
- Furosemide Impurity 25 (CAS 2309462-39-1)
- Furosemide Impurity 47 (CAS CATO-C4X-140247)
- Furosemide Impurity 9 (CAS CATO-C4X-14029)
- Furosemide Impurity 48 Sodium Salt (CAS 133989-65-8（free base）)
Recommended Standards
- 2-(5-(Chloromethyl)-1,2,4-oxadiazol-3-yl)-N-(4-sulfamoylphenyl)acetamide (CAS 885461-52-9)
- N4-(5-Chloro-2-methoxyphenyl)-N2-(3-hydroxypropyl)-L-asparagine (CAS 1026770-21-7)
- N4-(2-Chlorophenyl)-N2-(2-(2-hydroxyethoxy)ethyl)-L-asparagine (CAS 1048007-05-1)
- Olaparib Impurity 96 (CAS CATO-C4X-113596)
- Eltrombopag Impurity 155 (CAS CATO-C4X-1198155)
- Lercanidipine Impurity 33 (CAS 927-73-1)
- Carbidopa Impurity 21 (CAS CATO-C4X-231021)
- 4-Chloroquinazoline-6-carbaldehyde (CAS 648449-05-2)
- 3-(isoquinolin-4-yl)prop-2-yn-1-ol (CAS 70437-17-1)
- 1-(2-Chloro-5-Fluoro-6-Methylaminopyridin-3-yl-2-(2-Dimethylaminoethoxy)Ethanol Hydrochloride (CAS 142934-88-1)
- 1-(2-Oxo-1,2,3,4-tetrahydroquinolin-6-yl)-3-(m-tolyl)urea (CAS 1170513-97-9)
- Methyl 4-fluoro-3-methoxyphenylacetate (CAS 1427397-59-8)
- 8-bromo-2-ethylsulfanyl-6-(trifluoromethyl)chromen-4-one (CAS 2715285-50-8)
- Semaglutide impurity 73 (CAS CATO-C4X-222673)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com