Salbutamol Impurity 71 CAS 232590-81-7
| CAS No. | 232590-81-7 |
| Molecular Formula | C12H19NO3 |
| Molecular Weight | 225.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Salbutamol Impurity 71 (CAS 232590-81-7, C12H19NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Salbutamol Impurity 71 (C12H19NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19NO3 |
| Molecular Weight | 225.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2023 |
| Nitrogen Atoms | 1 |
Related Salbutamol Standards
- Salbutamol Impurity 68 (CAS 18910-63-9)
- Salbutamol Impurity 69 (CAS 18866-78-9)
- Salbutamol Impurity 196 (CAS CATO-C4X-1176196)
- Salbutamol EP Impurity C (CAS 18910-68-4)
- Salbutamol Impurity 84 (CAS CATO-C4X-117684)
- Salbutamol Impurity 55 (CAS 115787-52-5)
- Salbutamol Impurity 92 (CAS CATO-C4X-117692)
- Salbutamol Impurity 67 (CAS CATO-C4X-117667)
Recommended Standards
- Terbutaline impurity 116 (CAS CATO-C4X-1183116)
- Terbutaline Impurity 24 (CAS CATO-C4X-118324)
- Vildagliptin Impurity 7 (CAS 1032564-18-3)
- Bisoprolol Impurity 120 (CAS 62340-37-8)
- Tofacitinib Impurity 217 (CAS CATO-C4X-1079217)
- Indapamide EP Impurity B (CAS 63968-75-2)
- Cefcapene Impurity 25 (CAS CATO-C4X-182425)
- 5-(Tert-butyl)-1H-indazole-3-carboxylic acid (CAS 1784521-12-5)
- Alcaftadine Impurity 1 (CAS 147083-93-0)
- 2-Methoxy-4-(1-propyl)phenol (CAS 2785-87-7)
- 3-(S-Methylsulfonimidoyl)benzonitrile (CAS 2361964-39-6)
- 9-Methyl-9h-carbazol-2-amine (CAS 86439-57-8)
- 3-(1,3-Dioxolan-2-yl)-4-fluorobenzonitrile (CAS 1823921-62-5)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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