Olopatadine Impurity 46 CAS 23560-66-9
| CAS No. | 23560-66-9 |
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Olopatadine Impurity 46 (CAS 23560-66-9, C15H12O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olopatadine Impurity 46 (C15H12O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Olopatadine Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
Related Olopatadine Standards
- Olopatadine impurity 147 (CAS CATO-C4X-1135147)
- Olopatadine Impurity 35 (CAS 89019-82-9)
- Olopatadine Impurity 30 (CAS 728-97-2)
- Olopatadine Impurity 45 (CAS 834-25-3)
- Olopatadine lmpurity 57 (CAS CATO-C4X-171857)
- Olopatadine Impurity 12 (CAS 66801-40-9)
- Olopatadine USP Related Compound C (CAS 55453-87-7)
- Olopatadine Impurity 37 (CAS 55689-64-0)
Recommended Standards
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- Fludarabine Phosphate Impurity 12 (CAS 25545-03-3)
- Canagliflozin Impurity 89 (CAS CATO-C4X-112389)
- Upadacitinib Impurity 6 (CAS CATO-C4X-24056)
- 2-(3-(3-Methyl-1,2,4-oxadiazol-5-yl)azetidin-1-yl)acetic acid hydrochloride (CAS 1426290-57-4)
- Ethyl 2-(4-chloro-3-methyl-1H-pyrazol-1-yl)butanoate (CAS 1171381-25-1)
- N-(Thiazolo[4,5-b]pyridin-2-yl)benzamide (CAS 100856-66-4)
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- 1-Bromo-5-methoxyisoquinoline-3-carboxylic acid (CAS 2137836-19-0)
- 2-Cyclopropoxy-4-nitrobenzonitrile (CAS 1243479-29-9)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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