Clotrimazole Impurity 19 CAS 23593-76-2
| CAS No. | 23593-76-2 |
| Molecular Formula | C22H17ClN2 |
| Molecular Weight | 344.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Clotrimazole Impurity 19 (C22H17ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Clotrimazole Impurity 19 (CAS 23593-76-2, C22H17ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clotrimazole Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H17ClN2 |
| Molecular Weight | 344.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clotrimazole Standards
- Clotrimazole TRAM-34 Impurity (CAS 289905-88-0)
- Clotrimazole EP Impurity B (CAS 23593-71-7)
- Clotrimazole (CAS 23593-75-1)
- Clotrimazole-d5 (CAS 1185076-41-8)
- Clotrimazole Impurity 23 (CAS 289887-34-9)
- Clotrimazole Impurity 24 (CAS 98751-53-2)
- Clotrimazole Impurity 29 (CAS 103855-36-3)
- Clotrimazole Impurity 9 (CAS 23593-68-2)
Recommended Standards
- Bifonazole Impurity 22 (CAS CATO-C4X-156022)
- Clozapine EP Impurity D (CAS 65514-71-8)
- Cetirizine Dihydrochloride EP Impurity B (CAS 942193-17-1)
- Cetirizine Impurity N19 (CAS 113740-61-7)
- Olaparib Impurity 120 (CAS CATO-C4X-1135120)
- Delafloxacin Impurity 15 (CAS CATO-C4X-263715)
- Polaprezinc Impurity 3 (CAS 103646-38-4)
- 4-Chloro-2-phenyl-8-(trifluoromethoxy)quinoline (CAS 1189106-99-7)
- 1-Methyl-3-(S-methylsulfonimidoyl)benzene(hydrochloride) (CAS 2219371-88-5)
- Betahistine Impurity N1 (CAS 1894608-21-9(free base))
- 2-(3,5-Dimethyl-1h-pyrazol-1-yl)pyridine-4-carboximidamide hydrochloride (CAS 1221724-18-0)
- Domperidone Impurity 22 (CAS 52099-72-6)
- 1-Aminocyclopropanol Hydrochloride (CAS 58939-46-1)
- Cholecystokinin Octapeptide (1-5) (desulfated) (CAS 121880-96-4)
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