3-Chloro-2,5-difluorophenylboronic acid CAS 2377610-17-6
| CAS No. | 2377610-17-6 |
| Molecular Formula | C6H4BClF2O2 |
| Molecular Weight | 192.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3-Chloro-2,5-difluorophenylboronic acid (CAS 2377610-17-6), a certified reference material (molecular formula C6H4BClF2O2, MW 192.36 g/mol) for analytical method development and quality control.
The molecular framework of 3-Chloro-2,5-difluorophenylboronic acid (C6H4BClF2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloro-2,5-difluorophenylboronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4BClF2O2 |
| Molecular Weight | 192.36 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (3-Chloro-2,6-difluorophenyl)boronic acid (CAS 1031226-45-5)
- (4-Chloro-2,3-difluorophenyl)boronic acid (CAS 1160561-28-3)
- (3-Chloro-2,4-difluorophenyl)boronic acid (CAS 1310384-18-9)
- 2-Chloro-4,6-difluorophenylboronic Acid (CAS 1373393-48-6)
- (2-Chloro-3,5-difluorophenyl)boronic acid (CAS 1451393-37-5)
- (3-Chloro-4,5-difluorophenyl)boronic acid (CAS 1643467-84-8)
- 2-Chloro-4,5-difluorophenylboronic acid (CAS 1801916-39-1)
- (4-Chloro-2,6-difluorophenyl)boronic acid (CAS 925911-61-1)
Recommended Standards
- 2-Chloro-3,6-difluorophenylboronic acid (CAS 2377608-42-7)
- 4-Chloro-2,5-difluorophenylboronic acid (CAS 2055778-26-0)
- 2-Chloro-3,4-difluorophenylboronic acid (CAS 2121511-30-4)
- 4-Chloro-3,5-difluorophenylboronic Acid (CAS 864759-63-7)
- 2,2-Dimethoxypropanamide (CAS 380482-29-1)
- tert-Butyl(3-chloropropoxy)dimethylsilane (CAS 89031-82-3)
- [1,1'-Biphenyl]-3,4',5-tricarbaldehyde (CAS 187281-19-2)
- Methyl but-3-yn-1-ylglycinate (CAS 1339628-96-4)
- 5-Iodo-2-(trifluoromethylthio)pyridine (CAS 1204234-47-8)
- 4-Chloro-5-(difluoromethyl)-2-methyl-3-nitropyridine (CAS 1805269-11-7)
- 5,6-Dihydroxycyclohex-5-ene-1,2,3,4-tetraone dihydrate (CAS 63183-44-8)
- N,N-Dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000574-06-0)
- 1-((4-Bromo-3,5-dimethyl-1h-pyrazol-1-yl)methyl)-3,5-dimethyl-1h-pyrazol-4-amine (CAS 956441-24-0)
- Prolactin-Releasing Peptide (1-31) (human) (CAS 215510-22-8)
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