Clotrimazole EP Impurity C CAS 42074-68-0
| CAS No. | 42074-68-0 |
| Molecular Formula | C19H14Cl2 |
| Molecular Weight | 313.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Clotrimazole EP Impurity C (CAS 42074-68-0), a pharmacopoeial impurity reference standard (molecular formula C19H14Cl2, MW 313.22 g/mol) used for the identification and quantification of trace impurities in APIs.
Clotrimazole EP Impurity C (C19H14Cl2) contains chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H14Cl2 |
| Molecular Weight | 313.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole Impurity 20 (CAS 27023-37-6)
- Clotrimazole Impurity 22 (CAS 59154-29-9)
- Clotrimazole EP Impurity F (CAS 15469-97-3)
- Clotrimazole Impurity 17 (CAS 717109-42-7)
- Clotrimazole Impurity 8 (CAS CATO-C4X-15698)
- Clotrimazole Impurity 18 (CAS 717109-43-8)
- Clotrimazole Impurity 9 (CAS 23593-68-2)
- Clotrimazole Impurity 29 (CAS 103855-36-3)
Recommended Standards
- Losartan Impurity 47 (CAS CATO-C4X-168347)
- Diclocymet (CAS 139920-32-4)
- Bifonazole Impurity 15 (CAS CATO-C4X-156015)
- Ac-3,5-dinitro-Tyr-OH (CAS 20767-00-4)
- Gefitinib Impurity 81 (CAS CATO-C4X-111781)
- Letermovir impurity 110 (CAS CATO-C4X-2915110)
- Linaclotide impurity 34 (CAS CATO-C4X-210634)
- 4-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine dihydrochloride (CAS 3415-33-6)
- 5-(benzylamino)-1-propyl-1,2-dihydropyridin-2-one (CAS 1179210-32-2)
- 2-((1-(2-(Trifluoromethyl)phenyl)ethoxy)carbonyl)benzoic acid (CAS 127733-45-3)
- (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) (CAS 132956-87-7)
- Ethyl 2-thioxo-2,3-dihydrobenzo[d]oxazole-5-carboxylate (CAS 162959-44-6)
- 2-Ethylpiperidin-4-one (CAS 1245698-19-4)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
Why CATO?
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