Larotrectinib Impurity 2 CAS 2409589-59-7
| CAS No. | 2409589-59-7 |
| Molecular Formula | C21H22F2N6O2 |
| Molecular Weight | 428.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Larotrectinib Impurity 2 (CAS 2409589-59-7, C21H22F2N6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Larotrectinib Impurity 2 (C21H22F2N6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Larotrectinib Impurity 2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H22F2N6O2 |
| Molecular Weight | 428.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Larotrectinib Standards
- Larotrectinib (CAS 1223403-58-4)
- Larotrectinib Impurity 1 (CAS 1223404-68-9)
- Larotrectinib Impurity 3 (CAS 2409590-08-3)
- Larotrectinib Impurity 15 (CAS CATO-C4X-238015)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
- Larotrectinib impurity 5 (CAS 2135871-21-3)
- Larotrectinib impurity 9 (CAS CATO-C4X-23809)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
Recommended Standards
- Ozenoxacin Impurity 58 (CAS CATO-C4X-279658)
- Tafluprost Impurity 4 (CAS CATO-C4X-21634)
- Finerenone Impurity 175 (CAS CATO-C4X-2880175)
- Nintedanib Impurity 107 (CAS CATO-C4X-1814107)
- Oseltamivir EP Impurity E（HCl） (CAS 208720-71-2(free base))
- Pramipexole Impurity 94 (CAS CATO-C4X-110794)
- Cladribine EP Impurity C (CAS 1839-18-5)
- Methyl 6-acetamido-4-(chloromethyl)picolinate (CAS 1393561-96-0)
- (S)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one (CAS 1427063-32-8)
- Zolmitriptan Impurity 33 Iodide (Mixture of Diastereomers) (CAS CATO-C4X-135133)
- (3-Aminoazetidin-1-yl)(4-methylthiazol-5-yl)methanone (CAS 1484288-86-9)
- 2-(2-Piperazin-1-ylethyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3-dione dihydrochloride (CAS 136369-09-0)
- Tirofiban Impurity 44 (CAS CATO-C4X-125444)
- (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) trifluoroacetate salt (CAS 2022956-55-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com