Larotrectinib Impurity 1 CAS 1223404-68-9
| CAS No. | 1223404-68-9 |
| Molecular Formula | C21H22F2N6O2 |
| Molecular Weight | 428.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Larotrectinib Impurity 1.
Larotrectinib Impurity 1 (CAS 1223404-68-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H22F2N6O2 and a molecular weight of 428.44 g/mol.
The molecular framework of Larotrectinib Impurity 1 (C21H22F2N6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Larotrectinib Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H22F2N6O2 |
| Molecular Weight | 428.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Larotrectinib Standards
- Larotrectinib (CAS 1223403-58-4)
- Larotrectinib Impurity 2 (CAS 2409589-59-7)
- Larotrectinib Impurity 3 (CAS 2409590-08-3)
- Larotrectinib Impurity 15 (CAS CATO-C4X-238015)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
- Larotrectinib impurity 5 (CAS 2135871-21-3)
- Larotrectinib impurity 9 (CAS CATO-C4X-23809)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
Recommended Standards
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com