Larotrectinib impurity 5 CAS 2135871-21-3
| CAS No. | 2135871-21-3 |
| Molecular Formula | C23H19F2N5O2 |
| Molecular Weight | 435.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Larotrectinib impurity 5 (CAS 2135871-21-3) is a certified pharmaceutical impurity reference standard with the molecular formula C23H19F2N5O2 and a molecular weight of 435.43 g/mol.
Based on its molecular formula C23H19F2N5O2, Larotrectinib impurity 5 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 435.43 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H19F2N5O2 |
| Molecular Weight | 435.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Larotrectinib Standards
- Larotrectinib impurity 9 (CAS CATO-C4X-23809)
- Larotrectinib Impurity 15 (CAS CATO-C4X-238015)
- Larotrectinib (CAS 1223403-58-4)
- Larotrectinib Impurity 1 (CAS 1223404-68-9)
- Larotrectinib Impurity 2 (CAS 2409589-59-7)
- Larotrectinib Impurity 3 (CAS 2409590-08-3)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
Recommended Standards
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- 2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-(pyridin-4-yl)acetic acid (CAS 885276-71-1)
- Olivetol (CAS 500-66-3)
- 1-Amino-2,5-anhydro-1-deoxy-D-mannitol (CAS 228862-97-3)
- 1-((3-((Trifluoromethyl)thio)pyrrolidin-1-yl)methyl)-1H-imidazole (CAS 1206524-57-3)
- 2-Fluoro-N-((6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)methyl)aniline (CAS 877812-00-5)
- Pancreatic Polypeptide (rat) (CAS 90419-12-8)
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