Larotrectinib Impurity 3 CAS 2409590-08-3
| CAS No. | 2409590-08-3 |
| Molecular Formula | C21H22F2N6O2 |
| Molecular Weight | 428.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Larotrectinib Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Larotrectinib Impurity 3 (CAS 2409590-08-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H22F2N6O2 and a molecular weight of 428.44 g/mol.
Based on its molecular formula C21H22F2N6O2, Larotrectinib Impurity 3 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 428.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H22F2N6O2 |
| Molecular Weight | 428.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Larotrectinib Standards
- Larotrectinib (CAS 1223403-58-4)
- Larotrectinib Impurity 1 (CAS 1223404-68-9)
- Larotrectinib Impurity 2 (CAS 2409589-59-7)
- Larotrectinib Impurity 15 (CAS CATO-C4X-238015)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
- Larotrectinib impurity 5 (CAS 2135871-21-3)
- Larotrectinib impurity 9 (CAS CATO-C4X-23809)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
Recommended Standards
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- 2-(2-Bromo-6-(methoxycarbonyl)pyridin-4-yl)acetic acid (CAS 1393557-18-0)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788677)
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