Amlodipine Impurity 36 CAS 331258-36-7
| CAS No. | 331258-36-7 |
| Molecular Formula | C28H25ClN2O7 |
| Molecular Weight | 536.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Amlodipine Impurity 36.
Amlodipine Impurity 36 (CAS 331258-36-7) is a certified pharmaceutical impurity reference standard with the molecular formula C28H25ClN2O7 and a molecular weight of 536.96 g/mol.
Amlodipine Impurity 36 (C28H25ClN2O7) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H25ClN2O7 |
| Molecular Weight | 536.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity 100 (CAS CATO-C4X-1095100)
- Amlodipine Besylate EP Impurity A (CAS 88150-62-3)
- Amlodipine Impurity 135 (CAS CATO-C4X-1095135)
- Amlodipine Impurity 140 (CAS CATO-C4X-1095140)
- Amlodipine impurity 130 (CAS CATO-C4X-1095130)
- Amlodipine Impurity 90 (CAS CATO-C4X-109590)
- Amlodipine Impurity 132 (CAS CATO-C4X-1095132)
- Amlodipine Aspartic Acid Impurity (CAS 400602-35-9)
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- Glucosamine Sulfate Impurity 5 (CAS 35061-50-8)
- 2-(4-Fluorophenoxy)-5-methylaniline (CAS 946683-05-2)
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