Vonoprazan Impurity N20 CAS 2416241-98-8
| CAS No. | 2416241-98-8 |
| Molecular Formula | C17H18FN3O2S |
| Molecular Weight | 347.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Vonoprazan Impurity N20 (CAS 2416241-98-8, C17H18FN3O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Vonoprazan Impurity N20 (C17H18FN3O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18FN3O2S |
| Molecular Weight | 347.41 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impurity 277 (CAS CATO-C4X-1020277)
- Vonoprazan Impurity 278 (CAS CATO-C4X-1020278)
- Vonoprazan Impurity 279 (CAS CATO-C4X-1020279)
- Vonoprazan Fumarate Impurity 18 (CAS 1883595-37-6)
- Vonoprazan Impurity 270 (CAS CATO-C4X-1020270)
- Vonoprazan Impurity 105 (CAS CATO-C4X-1020105)
- Vonoprazan Impurity 106 (CAS CATO-C4X-1020106)
- Vonoprazan Impurity 107 (CAS CATO-C4X-1020107)
Recommended Standards
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- Bilastine impurity 59 (CAS CATO-C4X-225359)
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- 2-{5-Oxo-4-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetonitrile (CAS 866149-42-0)
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- Methyl 3-acetyl-5-bromo-2-methylbenzoate (CAS 1638759-86-0)
- 6-Chloro-2-(difluoromethyl)-5-methoxypyridine-3-sulfonamide (CAS 1805406-99-8)
- Peptide WE-14 (CAS 115136-18-0)
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