Entacapone Impurity 29 CAS 2454-72-0
| CAS No. | 2454-72-0 |
| Molecular Formula | C8H7NO5 |
| Molecular Weight | 197.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Entacapone Impurity 29.
Entacapone Impurity 29 (CAS 2454-72-0) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7NO5 and a molecular weight of 197.14 g/mol.
Based on its molecular formula C8H7NO5, Entacapone Impurity 29 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 197.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7NO5 |
| Molecular Weight | 197.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Entacapone Standards
- Entacapone Impurity 25 (CAS 6635-20-7)
- Entacapone Impurity 28 (CAS 2450-26-2)
- Entacapone Impurity 31 (CAS 80547-69-9)
- Entacapone Impurity 32 (CAS CATO-C4X-162932)
- Entacapone Impurity 33 (CAS 144683-49-8)
- Entacapone Impurity 34 (CAS 144683-48-7)
- Entacapone Impurity N5 (CAS 2426-86-0)
- Entacapone EP Impurity E (CAS 7659-29-2)
Recommended Standards
- Sodium aminosalicylate Impurity 5 (CAS 15540-79-1)
- Pomalidomide Impurity 62 (CAS CATO-C4X-135462)
- Mesalazine Impurity 24 (CAS 859964-08-2)
- Apremilast Impurity 87 (CAS 202262-76-8)
- Mirogabalin Impurity 20 (CAS CATO-C4X-292420)
- Vitamin K1 Impurity 50 (CAS CATO-C4X-220750)
- Brivaracetam Impurity 88 (CAS 2096999-79-8)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(2-methoxyethyl)amino)-2-methylpropanoic acid (CAS 2172066-89-4)
- (5-((Trifluoromethyl)thio)pyridin-3-yl)methanamine (CAS 1204234-24-1)
- [4-(Oxetan-3-yloxy)phenyl]methanamine hydrochloride (CAS 1439900-28-3)
- Calcium Folinate Hydrate (CAS 2060570-47-8)
- Aclidinium bromide Impurity 1 (CAS 26878-13-7)
- rac-Erythro-3-hydroxy-DL-ornithine MonoHCl (CAS 66954-83-4)
- Semaglutide impurity 28 (CAS CATO-C4X-222628)
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