Entacapone Impurity 25 CAS 6635-20-7
| CAS No. | 6635-20-7 |
| Molecular Formula | C8H7NO5 |
| Molecular Weight | 197.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Entacapone Impurity 25 (CAS 6635-20-7) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7NO5 and a molecular weight of 197.14 g/mol.
Based on its molecular formula C8H7NO5, Entacapone Impurity 25 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 197.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7NO5 |
| Molecular Weight | 197.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Entacapone Standards
- Entacapone Impurity 28 (CAS 2450-26-2)
- Entacapone Impurity 29 (CAS 2454-72-0)
- Entacapone Impurity 31 (CAS 80547-69-9)
- Entacapone Impurity 32 (CAS CATO-C4X-162932)
- Entacapone Impurity 33 (CAS 144683-49-8)
- Entacapone Impurity 34 (CAS 144683-48-7)
- Entacapone Impurity N5 (CAS 2426-86-0)
- Entacapone EP Impurity E (CAS 7659-29-2)
Recommended Standards
- Sodium aminosalicylate Impurity 5 (CAS 15540-79-1)
- Pomalidomide Impurity 62 (CAS CATO-C4X-135462)
- Mesalazine Impurity 24 (CAS 859964-08-2)
- Apremilast Impurity 87 (CAS 202262-76-8)
- Tivozanib Impurity 9 (CAS 1808274-21-6)
- Azithromycin Impurity 10 (CAS 217500-34-0)
- Trazodone Impurity 89 (CAS CATO-C4X-177289)
- 3,6-Dibromo-5-methoxy-1H-pyrrolo[3,2-b]pyridine (CAS 1000341-07-0)
- Capivasertib Impurity 38 (CAS CATO-C4X-331238)
- 4-(3,4-Difluorophenyl)tetrahydro-2H-pyran-4-amine (CAS 1343262-94-1)
- (2-Chloro-5-nitrophenyl)hydrazine (CAS 96701-59-6)
- (S)-1-(4-(azepan-1-ylsulfonyl)phenyl)-2-bromoethan-1-ol (CAS 1175852-29-5)
- 4-((2,5-Dimethoxyphenyl)amino)-4-oxobut-2-enoic acid (CAS 284488-69-3)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
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