Entacapone EP Impurity E CAS 7659-29-2
| CAS No. | 7659-29-2 |
| Molecular Formula | C6H4N2O6 |
| Molecular Weight | 200.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Entacapone EP Impurity E (C6H4N2O6) contains a carbohydrate-derived structure, an amide group. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Entacapone EP Impurity E (CAS 7659-29-2, C6H4N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4N2O6 |
| Molecular Weight | 200.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 2 |
Related Entacapone Standards
- Entacapone Impurity 25 (CAS 6635-20-7)
- Entacapone Impurity 28 (CAS 2450-26-2)
- Entacapone Impurity 29 (CAS 2454-72-0)
- Entacapone Impurity 31 (CAS 80547-69-9)
- Entacapone Impurity 32 (CAS CATO-C4X-162932)
- Entacapone Impurity 33 (CAS 144683-49-8)
- Entacapone Impurity 34 (CAS 144683-48-7)
- Entacapone Impurity N5 (CAS 2426-86-0)
Recommended Standards
- Oxetan-3-yl (2,2,2-trifluoroethyl) carbonate (CAS 2138427-54-8)
- Acipimox impurity 22 (CAS CATO-C4X-186622)
- 6-Hydroxy-5-nitro-4-oxo-1,4-dihydropyridine-3-carboxylic acid (CAS 685542-71-6)
- 2-Amino-3-fluoro-5-nitrobenzoic acid (CAS 101336-14-5)
- Vericiguat Impurity 100 (CAS 1011527-86-8)
- SM7280A Impurity 3 (CAS CATO-C4X-32963)
- Finerenone Impurity 45 (CAS CATO-C4X-288045)
- 2-[2-[(tert-Butoxycarbonyl)amino]ethoxy]ethanol (CAS 139115-91-6)
- (R)-tert-Butyl 2-((R)-2-amino-3-methoxy-3-oxopropyl)pyrrolidine-1-carboxylate (CAS 2756662-42-5)
- 9-(3-Bromophenyl)-10-(naphthalen-2-yl)anthracene (CAS 943861-20-9)
- 3-Amino-5-bromo-2-fluorobenzoic acid (CAS 1339056-03-9)
- 5-Bromo-2,3-dihydro-7-iodo-1,4-dioxino[2,3-c]pyridine (CAS 2757008-36-7)
- 5-Acetamido-2-methoxybenzene-1-sulfonyl chloride (CAS 5804-73-9)
- Tirzepatide Impurity 19 X TFA Salt (CAS CATO-C4X-324019)
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