Sacubitril impurity 12 CAS 2459446-56-9
| CAS No. | 2459446-56-9 |
| Molecular Formula | C18H19NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 317.81 g/mol gives Sacubitril impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Sacubitril impurity 12 (CAS 2459446-56-9), a pharmacopoeial impurity reference standard (molecular formula C18H19NO2HCl, MW 317.81 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Sacubitril impurity 12 (C18H19NO2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Sacubitril impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H19NO2 HCl |
| Molecular Weight | 317.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril impurity 41 (CAS 1038924-61-6)
- Sacubitril Impurity 5 (CAS 1038925-00-6)
- Sacubitril Lactam (CAS 1038925-22-2)
- Sacubitril impurity 50 (CAS 1039307-95-3（free base）)
- Sacubitril Sodium Salt (CAS 149690-05-1)
- Sacubitril impurity 54 (CAS 149709-63-7)
- Sacubitril Impurity 55 (CAS 149818-98-4)
- Sacubitril impurity 18 (CAS 1810778-75-6)
Recommended Standards
- Deruxtecan Impurity 6 (CAS CATO-C4X-30576)
- Olaparib Impurity 112 (CAS 2231236-77-2)
- Flupentixol Impurity 45 (CAS CATO-C4X-189545)
- (3-Chloro-5-(trifluoromethoxy)phenyl)boronic acid (CAS 1451393-40-0)
- Novobiocin Sodium Salt (CAS 1476-53-5)
- 1-[(2,3-Dichlorophenyl)carbonyl]piperidine (CAS 916031-18-0)
- Ethyl 2-(3-chloro-5-methyl-1H-pyrazol-1-yl)acetate (CAS 1015779-06-2)
- 4-Chloro-2-methyl-1-(phenylsulfonyl)benzene (CAS 24539-54-6)
- 73215-11-9 YY4DOC4P28 1-(1-Ethylpropyl)-5,6-dimethyl-7-nitro-1H-benzimidazole 1H-Benzimidazole, 1-(1-ethylpropyl)-5,6-dimethyl-7-nitro- UNII-YY4DOC4P28 (CAS 73215-11-9)
- Insulin aspart (CAS 116094-23-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com