Sildenafil Impurity 243 CAS 247584-10-7
| CAS No. | 247584-10-7 |
| Molecular Formula | C8H14N4O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Sildenafil Impurity 243 (CAS 247584-10-7) is a certified pharmaceutical impurity reference standard with the molecular formula C8H14N4OHCl and a molecular weight of 218.69 g/mol.
Based on its molecular formula C8H14N4OHCl, Sildenafil Impurity 243 contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 218.69 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H14N4O HCl |
| Molecular Weight | 218.69 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Sildenafil Standards
- Sildenafil Impurity N6 (CAS 1004455-71-3)
- Sildenafil Impurity 258 (CAS 1007310-62-4)
- Sildenafil Impurity 256 (CAS 1027192-9-2)
- Sildenafil Impurity 5 (CAS 1058653-74-9)
- Sildenafil Impurity 29 (CAS 1093065-15-6)
- Sildenafil EP Impurity B (CAS 1094598-75-0)
- Sildenafil-D3 (CAS 1126745-90-1)
- Sildenafil Impurity 62 (CAS 116833-23-9)
Recommended Standards
- Cinacalcet impurity 87 (CAS CATO-C4X-105987)
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- Ceftazidime Impurity 33 (CAS CATO-C4X-121233)
- cis-Bis(2,2?-bipyridine)dichloroosmium(II) (CAS 79982-56-2)
- 4-{[2-chloro-5-(trifluoromethyl)phenyl]carbamoyl}phenyl N,N-dimethylsulfamate (CAS 338396-26-2)
- (4-(2-Methyl-1H-imidazol-5-yl)phenyl)methanol (CAS 1365968-91-7)
- 3-(3-Chloropyridin-4-yl)-2,2-dimethylpropanoic acid (CAS 1482200-40-7)
- Chlorotrimethylgermane (CAS 1529-47-1)
- 6-Fluoro-2-iodopyridin-3-ol (CAS 214911-10-1)
- Tirzepatide Impurity 14 (CAS CATO-C4X-324014)
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