Camptothecin Impurity 11 CAS 2569708-76-3
| CAS No. | 2569708-76-3 |
| Molecular Formula | C21H18N2O6 |
| Molecular Weight | 394.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Camptothecin Impurity 11 (CAS 2569708-76-3, C21H18N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Camptothecin Impurity 11 (C21H18N2O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H18N2O6 |
| Molecular Weight | 394.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 2 |
Related Camptothecin Standards
- Camptothecin Impurity 13 (CAS 91421-42-0)
- Camptothecin impurity 19 (CAS CATO-C4X-157119)
- Camptothecin impurity 18 (CAS 19685-11-1)
- Camptothecin Impurity 15 (CAS CATO-C4X-157115)
- Camptothecin Impurity 8 (CAS 86639-53-4)
- Camptothecin Impurity 12 (CAS 19685-10-0)
- 11-Ethyl Camptothecin (CAS 185807-29-8)
- Camptothecin Impurity 10 (CAS 68426-53-9)
Recommended Standards
- Methotrexate impurity 55 (CAS CATO-C4X-115455)
- Bepotastine Impurity 17 (CAS CATO-C4X-183917)
- Phenobarbital N-b-D-Glucoside (CAS 72209-10-0)
- Roxadustat Impurity 176 (CAS CATO-C4X-2213176)
- Levosimendan Impurity 57 (CAS CATO-C4X-130857)
- Lemborexant Impurity 21 (CAS CATO-C4X-304221)
- Aripiprazole Impurity 37 (CAS 63386-61-8)
- (3R,4S)-3-Amino-4-methyloxetan-2-one 4-methylbenzenesulfonate (CAS 1237534-99-4)
- 4-(Phenylethynyl)phenol (CAS 1849-26-9)
- 2-(1-[(tert-Butoxy)carbonyl]hydrazin-1-yl)ethan-1-ol (CAS 114897-60-8)
- 17-Methoxycarbonyl Loteprednol (CAS 265651-89-6)
- 4-Acetyl-n-butylbenzene-1-sulfonamide (CAS 733031-17-9)
- 1-((3,4-Difluorophenyl)sulfonyl)piperazine (CAS 790271-21-5)
- Semaglutide impurity 97 (CAS CATO-C4X-222697)
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