Camptothecin Impurity 8 CAS 86639-53-4
| CAS No. | 86639-53-4 |
| Molecular Formula | C23H22N2O5 |
| Molecular Weight | 406.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Camptothecin Impurity 8 (CAS 86639-53-4, C23H22N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Camptothecin Impurity 8 (C23H22N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Camptothecin Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H22N2O5 |
| Molecular Weight | 406.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 2 |
Related Camptothecin Standards
- Camptothecin Impurity 15 (CAS CATO-C4X-157115)
- Camptothecin impurity 18 (CAS 19685-11-1)
- Camptothecin Impurity 11 (CAS 2569708-76-3)
- Camptothecin Impurity 13 (CAS 91421-42-0)
- Camptothecin impurity 19 (CAS CATO-C4X-157119)
- Camptothecin Impurity 12 (CAS 19685-10-0)
- 11-Ethyl Camptothecin (CAS 185807-29-8)
- Camptothecin Impurity 10 (CAS 68426-53-9)
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