Camptothecin Impurity 12 CAS 19685-10-0
| CAS No. | 19685-10-0 |
| Molecular Formula | C21H18N2O5 |
| Molecular Weight | 378.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Camptothecin Impurity 12 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Camptothecin Impurity 12 (CAS 19685-10-0) is a certified pharmaceutical impurity reference standard with the molecular formula C21H18N2O5 and a molecular weight of 378.38 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Camptothecin Impurity 12 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 378.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18N2O5 |
| Molecular Weight | 378.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 2 |
Related Camptothecin Standards
- 11-Ethyl Camptothecin (CAS 185807-29-8)
- Camptothecin impurity 19 (CAS CATO-C4X-157119)
- Camptothecin Impurity 10 (CAS 68426-53-9)
- Camptothecin impurity 17 (CAS 86639-48-7)
- Camptothecin Impurity 9 (CAS 67656-30-8)
- Camptothecin Impurity 13 (CAS 91421-42-0)
- 7-Methyl Camptothecin (CAS 78287-26-0)
- Camptothecin Impurity 11 (CAS 2569708-76-3)
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