Norethindrone Impurity 8 CAS 25796-09-2
| CAS No. | 25796-09-2 |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Norethindrone Impurity 8 (CAS 25796-09-2, C20H30O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Norethindrone Impurity 8 (C20H30O2) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
Related Norethindrone Standards
- Norethindrone Impurity 5 (CAS 16392-60-2)
- Norethindrone Impurity 6 (CAS 6424-05-1)
- Norethindrone-D6 (CAS CATO-CCAD301120)
- Norethindrone (CAS 68-22-4)
- 6-Oxo Norethindrone (CAS 67696-78-0)
- Norethindrone 6-alpha-Hydroxy Impurity (CAS 438244-33-8)
- Norethindrone Impurity 23 (6-beta-Hydroxy-19-Norandrostenedione) (CAS 5949-49-5)
- Norethindrone Acetate (CAS 38673-38-0)
Recommended Standards
- Oxendolone (CAS 33765-68-3)
- N-(Cyclohexylmethyl)-N-(4-methoxybenzyl)pyrrolidin-3-amine (CAS 820984-35-8)
- Polyprenic (CAS 81485-25-8)
- N-(2,2,4-Trimethyl-1-pentyl-1,2,3,4-tetrahydroquinolin-7-yl)acetamide (CAS 90312-25-7)
- Sitafloxacin impurity 78 (CAS CATO-C4X-115578)
- Maribavir Impurity 28 (CAS CATO-C4X-300728)
- Ruxolitinib Impurity 156 D-Tartrate (CAS 2102675-37-4)
- Secologanoside (CAS 59472-23-0)
- Benzyl octahydro-6H-pyrido[3,4-b][1,4]thiazine-6-carboxylate (CAS 2306262-30-4)
- 4-(((2,6-Dimethylphenyl)imino)methyl)-1,2-dihydro-3H-pyrazol-3-one (CAS 339107-20-9)
- Relugolix Impurity 77 (CAS CATO-C4X-242977)
- 4-(Aminomethyl)benzo[d]thiazol-2-amine (CAS 1145679-26-0)
- 1-(1h-Benzo[d]imidazol-2-yl)-3-methylbutan-1-amine hydrochloride (CAS 1177352-51-0)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com