Norethindrone Impurity 6 CAS 6424-05-1
| CAS No. | 6424-05-1 |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Norethindrone Impurity 6 (C20H30O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Norethindrone Impurity 6 (CAS 6424-05-1, C20H30O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Norethindrone Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Norethindrone Standards
- Norethindrone Impurity 5 (CAS 16392-60-2)
- Norethindrone Impurity 8 (CAS 25796-09-2)
- Norethindrone-D6 (CAS CATO-CCAD301120)
- Norethindrone (CAS 68-22-4)
- 6-Oxo Norethindrone (CAS 67696-78-0)
- Norethindrone 6-alpha-Hydroxy Impurity (CAS 438244-33-8)
- Norethindrone Impurity 23 (6-beta-Hydroxy-19-Norandrostenedione) (CAS 5949-49-5)
- Norethindrone Acetate (CAS 38673-38-0)
Recommended Standards
- N-(Cyclohexylmethyl)-N-(4-methoxybenzyl)pyrrolidin-3-amine (CAS 820984-35-8)
- N-(2,2,4-Trimethyl-1-pentyl-1,2,3,4-tetrahydroquinolin-7-yl)acetamide (CAS 90312-25-7)
- Oxendolone (CAS 33765-68-3)
- Mibolerone CIII (1443362) (CAS 3704-09-4)
- (Z)-Sodium aminosalicylate Impurity 4 (CAS 318515-20-7)
- Pentoxifylline impurity 35 (CAS CATO-C4X-172835)
- Avanafil Impurity 19 (CAS 2250242-12-5)
- 1-(2,4-Difluorophenyl)cyclobutanecarboxylic Acid (CAS 1260672-69-2)
- 2-Dihydro Boceprevir (CAS 394735-28-5)
- (2,6-Dimethylphenyl)(oxazol-2-yl)methanone (CAS 898784-48-0)
- 2-(4-Bromo-2-chlorophenoxy)-N,N-diethylethanamine (CAS 1142945-00-3)
- 3-Chloro-6-phenylpyridazine-4-carboxamide (CAS 118269-69-5)
- Ethyl 4-chloro-1-cyclopentyl-1H-pyrazole-3-carboxylate (CAS 1856041-27-4)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
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