Clopidogrel Impurity 87 CAS 26118-14-9
| CAS No. | 26118-14-9 |
| Molecular Formula | C8H5ClO3 |
| Molecular Weight | 184.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Clopidogrel Impurity 87 (CAS 26118-14-9, C8H5ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Clopidogrel Impurity 87 (C8H5ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClO3 |
| Molecular Weight | 184.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
Related Clopidogrel Standards
- Clopidogrel Impurity 16 (CAS 138228-61-2)
- Clopidogrel Impurity 12 (CAS 141196-64-7)
- Clopidogrel Impurity 67 (CAS 7292-71-9)
- Clopidogrel Impurity 68 (CAS 6212-33-5)
- Clopidogrel Impurity 69 (CAS 131202-62-5)
- Clopidogrel Impurity 88 (CAS 34966-49-9)
- Clopidogrel Impurity 98 (CAS 76103-96-3)
- Clopidogrel Impurity 5 (CAS 141109-16-2)
Recommended Standards
- 8-Chloro-7-methylpyrazolo[1,5-a][1,3,5]triazin-4(1H)-one (CAS 55457-65-3)
- Palbociclib Impurity 181 (CAS 2601903-88-0)
- 7-chlorobenzo[d][1,3]dioxole-5-carbaldehyde (CAS 88525-51-3)
- Norepinephrine Impurity 158 (CAS CATO-C4X-1514158)
- Sulbactam Impurity 36 (CAS CATO-C4X-175636)
- Avibactam Impurity 74 (CAS 2523-37-7)
- Azithromycin Impurity 47 (CAS CATO-C4X-100347)
- (S)-6-bromo-1,2,3,4-tetrahydronaphthalen-1-ol (CAS 1567965-64-3)
- 4-(Cyclohexyloxy)-3-methoxyphenol (CAS 1243443-39-1)
- 1-((3-Bromothiophen-2-yl)methyl)-1h-1,2,4-triazol-3-amine (CAS 1250797-66-0)
- 2-(Chloromethyl)-3-(difluoromethyl)-5-iodopyridine-4-methanol (CAS 1806024-27-0)
- 2-Chloro-4,5-difluorobenzamide (CAS 296274-32-3)
- {1-[(2,6-dimethylphenyl)amino]propan-2-yl}dimethylamine (CAS 83843-49-6)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
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