3-Chloro-2-fluoro-5-(trifluoromethyl)benzyl alcohol CAS 261763-05-7
| CAS No. | 261763-05-7 |
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-2-fluoro-5-(trifluoromethyl)benzyl alcohol (CAS 261763-05-7), molecular formula C8H5ClF4O and molecular weight 228.57 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 3-Chloro-2-fluoro-5-(trifluoromethyl)benzyl alcohol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 228.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (2-Chloro-6-fluoro-4-(trifluoromethyl)phenyl)hydrazine (CAS 110499-66-6)
- 1-(4-Chloro-3-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1247205-10-2)
- 1-(2-Chloro-6-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1249544-27-1)
- 2-[Chloro(difluoro)methoxy]-1,3-difluoro-4-methyl-benzene (CAS 1404194-29-1)
- 1-[Chloro(difluoro)methoxy]-2,3-difluoro-4-methyl-benzene (CAS 1404194-41-7)
- (4-Chloro-3-fluoro-5-(trifluoromethyl)phenyl)methanol (CAS 1431329-65-5)
- (3-Chloro-2-fluoro-4-(trifluoromethyl)phenyl)methanol (CAS 1431329-79-1)
- 3-Chloro-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1447606-46-3)
Recommended Standards
- 2-Chloro-5-fluoro-3-(trifluoromethyl)benzyl alcohol (CAS 2056110-51-9)
- 3-Chloro-2-fluoro-6-(trifluoromethyl)benzyl alcohol (CAS 261763-06-8)
- 1-Chloro-4-(1,1,2,2-tetrafluoroethoxy)benzene (CAS 75820-58-5)
- 4-Chloro-2-fluoro-1-(2,2,2-trifluoroethoxy)benzene (CAS 918524-44-4)
- 1-(3-Methyl-1h-pyrazol-1-yl)propan-2-amine (CAS 957261-74-4)
- Methyl 4-iodobicyclo[2.2.1]Heptane-1-carboxylate (CAS 123463-12-7)
- n-Methyl-n-(propan-2-yl)piperidine-3-carboxamide (CAS 1016708-29-4)
- 3-Bromo-1-(difluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 1713589-83-3)
- 4-Tritylaniline Hydrochloride (CAS 945018-87-1)
- 1,4-Dichloro-2-methyl-3-nitrobenzene (CAS 1803830-16-1)
- 5-(Bromomethyl)-2-chloro-4-methylpyridine (CAS 1496561-18-2)
- 1-Ethyl-3,5-dimethyl-4-(pyrrolidin-2-yl)-1H-pyrazole (CAS 1710472-39-1)
- 4-Hydroxy-1-methyl-N-(3-methylphenyl)-2,2-dioxo-1,2-dihydro-2lambda~6~,1-benzothiazine-3-carboxamide (CAS 320423-83-4)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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