Alprazolam EP Impurity B CAS CATO-C4X-146014
| CAS No. | CATO-C4X-146014 |
| Molecular Formula | C18H16ClN3O |
| Molecular Weight | 325.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 325.79 g/mol gives Alprazolam EP Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Alprazolam EP Impurity B (CAS CATO-C4X-146014) is a certified pharmaceutical impurity reference standard with the molecular formula C18H16ClN3O and a molecular weight of 325.79 g/mol.
The molecular framework of Alprazolam EP Impurity B (C18H16ClN3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Alprazolam EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16ClN3O |
| Molecular Weight | 325.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Alprazolam Standards
- Alprazolam Impurity 8 (CAS 30896-65-2)
- Alprazolam EP Impurity B (CAS 38150-27-5)
- Alprazolam EP Impurity D (CAS CATO-C4X-146010)
- Alprazolam impurity 21 (CAS 37945-06-5)
- Alprazolam Impurity 16 (CAS CATO-C4X-146016)
- Alprazolam-D5 (CAS 125229-61-0)
- Alprazolam-D5 (1.0 mg/mL in Methanol) (CAS 1286073-82-2)
- Alprazolam 5,6-Epoxide (CAS 36916-14-0)
Recommended Standards
- 4-(3-Chloro-phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid 4207AE 486991-75-7 C19H16ClNO2 (CAS 486991-75-7)
- 4-(2-Benzhydrylhydrazinyl)-6-chloropyrimidin-5-amine (CAS 15129-00-7)
- trans-1-Boc-4-(4-chlorophenyl)-pyrrolidine-3-carboxylic acid (CAS 851485-00-2)
- 6-Chloro-N2,N4-di-m-tolyl-1,3,5-triazine-2,4-diamine (CAS 62752-05-0)
- Mianserin Impurity 80 (CAS 1260761-23-6)
- Etizolam Impurity 4 (CAS 110753-14-5)
- Benzylpenicillin (Benzathine) Tetrahydrate EP Impurity A (CAS 4152-09-4)
- Ethyl 8-amino-3,4-dihydro-2h-benzo[b][1,4]dioxepine-7-carboxylate (CAS 1179202-94-8)
- 3-(1-Oxoisoindolin-2-yl)-3-(thiophen-2-yl)propanoic acid (CAS 478079-05-9)
- Disperse Yellow 3-D3 (CAS 947601-96-9)
- 3-Fluoro-N-(prop-2-yn-1-yl)isonicotinamide (CAS 1437485-26-1)
- 4-(Benzyloxy)-2-tert-butylphenol (CAS 3421-95-2)
- 2-Chloro-4-(1,1-difluoroethyl)-1-fluorobenzene (CAS 1138444-93-5)
- Tau Peptide (74-102) (Exon 3/Insert 2 Domain) trifluoroacetate salt (CAS 1322695-34-0)
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