Tofacitinib Impurity 70 CAS 2640342-78-3
| CAS No. | 2640342-78-3 |
| Molecular Formula | C13H21N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Tofacitinib Impurity 70 (CAS 2640342-78-3), a pharmacopoeial impurity reference standard (molecular formula C13H21N5HCl, MW 283.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tofacitinib Impurity 70 (C13H21N5HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 283.80 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Tofacitinib Impurity 70 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H21N5 2*HCl |
| Molecular Weight | 283.80 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Pranlukast Impurity 1 (CAS 136450-10-7)
- Bilastine impurity 86 (CAS CATO-C4X-225386)
- Apalutamide Impurity 17 (CAS CATO-C4X-274917)
- 1-(2-Aminoethyl)piperazin-2-one (CAS 356069-02-8)
- Methyl 5-bromo-2,3-difluorobenzoate (CAS 1150163-69-1)
- tert-butyl (3R,4R)-3-fluoro-4-methylsulfonyloxy-pyrrolidine-1-carboxylate (CAS 1610417-31-6)
- Levofloxacin EP Impurity D(Hydrochloride) (CAS CATO-C4X-137127)
- 3-propoxybenzonitrile (CAS 467462-55-1)
- 5-Bromo-1H-indole-3-sulfonyl chloride (CAS 2086186-32-3)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com