Bumetanide Impurity 103 CAS 267014-44-8
| CAS No. | 267014-44-8 |
| Molecular Formula | C7H6N2O5 |
| Molecular Weight | 198.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bumetanide Impurity 103 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Bumetanide Impurity 103 (CAS 267014-44-8) is a certified pharmaceutical impurity reference standard with the molecular formula C7H6N2O5 and a molecular weight of 198.13 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Bumetanide Impurity 103 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 198.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6N2O5 |
| Molecular Weight | 198.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Bumetanide Standards
- Bumetanide Impurity 64 (CAS CATO-C4X-198664)
- Bumetanide Impurity 45 (CAS 860694-39-9)
- Bumetanide Impurity 44 (CAS 84211-27-8)
- Bumetanide Impurity 75 (CAS CATO-C4X-198675)
- Bumetanide Impurity 105 (CAS CATO-C4X-1986105)
- Bumetanide Impurity 43 (CAS 6633-36-9)
- Bumetanide Impurity 41 (CAS 20532-06-3)
- Bumetanide Impurity 26 (CAS CATO-C4X-198626)
Recommended Standards
- 4-Amino-3-hydroxy-5-nitrobenzoic acid (CAS 1394916-93-8)
- Puberulic Acid (CAS 99-23-0)
- Tegoprazan Impurity 65 (CAS CATO-C4X-229765)
- 2,5-Dihydroxyterephthalic acid (CAS 610-92-4)
- Levocabastine EP Impurity H (CAS CATO-C4X-22898)
- Amifostine Impurity 1 (CAS 23545-42-8)
- Latanoprost EP Impurity H (CAS 41639-83-2)
- 5-(4-Nitrophenyl)cyclohexane-1,3-dione (CAS 55579-75-4)
- tert-Butyl (3-amino-1,1,1-trifluoropropan-2-yl)carbamate (CAS 1429913-34-7)
- 3-((2-Chloro-6-fluorobenzyl)thio)-5-propyl-4H-1,2,4-triazol-4-amine (CAS 459210-10-7)
- 1-(Tert-butyl) 3-methyl 2,2-dimethylazetidine-1,3-dicarboxylate (CAS 2446668-76-2)
- 3-(4-Chlorophenyl)-5-ethylisoxazole-4-carboxylic acid (CAS 91961-52-3)
- TNP-470 (CAS 129298-91-5)
- Tirzepatide Impurity 15 (CAS CATO-C4X-324015)
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