Bumetanide Impurity 43 CAS 6633-36-9
| CAS No. | 6633-36-9 |
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Bumetanide Impurity 43 (CAS 6633-36-9), a pharmacopoeial impurity reference standard (molecular formula C8H10N2O2, MW 166.18 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Bumetanide Impurity 43 (C8H10N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Bumetanide Standards
- Bumetanide Impurity 44 (CAS 84211-27-8)
- Bumetanide Impurity 103 (CAS 267014-44-8)
- Bumetanide Impurity 64 (CAS CATO-C4X-198664)
- Bumetanide Impurity 45 (CAS 860694-39-9)
- Bumetanide Impurity 75 (CAS CATO-C4X-198675)
- Bumetanide Impurity 105 (CAS CATO-C4X-1986105)
- Bumetanide Impurity 41 (CAS 20532-06-3)
- Bumetanide Impurity 26 (CAS CATO-C4X-198626)
Recommended Standards
- Nicorandil Impurity 57 (CAS 342018-76-2)
- Pyridostigmine Bromide EP Impurity A (CAS 51581-32-9)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- N-(3-methoxyphenyl)-N-methylnitrous amide (CAS 18559-18-7)
- Cefmetazole Impurity 1 (CAS 56796-16-8)
- Mirabegron Impurity 62 (CAS CATO-C4X-103262)
- Fluralaner impurity 30 (CAS CATO-C4X-218030)
- 2-(2-Fluorophenoxy)-N-(4-(2-(methylamino)-2-oxoethyl)phenyl)acetamide (CAS 1060252-34-7)
- Methyl 2-ethoxypyridine-4-carboxylate (CAS 153928-57-5)
- 2-[(3-Bromophenyl)methyl]-5-phenyl-2,5-dihydro-1,2-oxazole (CAS 939893-30-8)
- 2-Chloro-5-(3-chlorophenyl)nicotinonitrile (CAS 338964-13-9)
- n-Butyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS 1219798-67-0)
- 1-(1H-Indazol-6-yl)ethanone (CAS 189559-85-1)
- Peptide Impurity 28 (CAS 1350456-64-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com