Etravirine Iimpurity 9 CAS 269055-19-8
| CAS No. | 269055-19-8 |
| Molecular Formula | C20H15ClN6O |
| Molecular Weight | 390.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Etravirine Iimpurity 9.
As a process- or degradation-related impurity, Etravirine Iimpurity 9 (CAS 269055-19-8, C20H15ClN6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Etravirine Iimpurity 9 (C20H15ClN6O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H15ClN6O |
| Molecular Weight | 390.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Etravirine Standards
- Etravirine Impurity N2 (CAS 1070377-34-2)
- Etravirine 6-Desamino 5-Chloro Impurity (CAS 269055-05-2)
- Etravirine Impurity 2 (CAS 1225383-64-1)
- Etravirine Impurity 3 (CAS CATO-C4X-13563)
- Etravirine Impurity N1 (CAS 939431-68-2)
- Etravirine Impurity 4 (CAS CATO-C4X-13564)
- Etravirine (CAS 269055-15-4)
- Etravirine-13C3 (CAS 1189671-48-4)
Recommended Standards
- Des(6-amino-5-bromo)-5-amino-6-chloro Etravirine (CAS 269055-78-9)
- 4-(4-((5-Chloro-2-methoxyphenyl)sulfonyl)piperazin-1-yl)-4-oxobutanoic acid (CAS 1110717-62-8)
- 7-Bromo-2,4,6,8-tetrachloro-3-nitroquinoline (CAS 2667057-47-6)
- 2,3-Dibromo-5-iodo-4,6-dimethylpyridine (CAS 1823961-40-5)
- Posaconazole Impurity 60 (CAS CATO-C4X-120860)
- Foritinib Impurity 8 (CAS CATO-C4X-33108)
- Sugammadex Impurity 26 (CAS CATO-C4X-190626)
- 3-Oxobutanoyl chloride (CAS 39098-85-6)
- N-(2-(naphthalen-2-yloxy)ethyl)-4-nitrobenzenesulfonamide (CAS 188444-66-8)
- 2-Amino-4-(4-chlorophenyl)-5,6-dimethylpyridine-3-carbonitrile (CAS 333394-03-9)
- 5-(Benzyloxy)-3-bromopyridin-2-amine (CAS 941596-78-7)
- Cyclopropyl 4-thiomethylphenyl ketone (CAS 99522-32-4)
- ([3-(2-Methoxyethyl)-1,2,4-oxadiazol-5-yl]methyl)amine hydrochloride 1119451-09-0 (CAS 1119451-09-0)
- Vancomycin Hexapeptide (CAS 115236-65-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com