Etravirine Impurity 3 CAS CATO-C4X-13563
| CAS No. | CATO-C4X-13563 |
| Molecular Formula | C20H14ClN5O |
| Molecular Weight | 375.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Etravirine Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Etravirine Impurity 3 (CAS CATO-C4X-13563, C20H14ClN5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Etravirine Impurity 3 (C20H14ClN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 375.81 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H14ClN5O |
| Molecular Weight | 375.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Etravirine Standards
- Etravirine Impurity N2 (CAS 1070377-34-2)
- Etravirine 6-Desamino 5-Chloro Impurity (CAS 269055-05-2)
- Etravirine Impurity 2 (CAS 1225383-64-1)
- Etravirine Iimpurity 9 (CAS 269055-19-8)
- Etravirine Impurity N1 (CAS 939431-68-2)
- Etravirine Impurity 4 (CAS CATO-C4X-13564)
- Etravirine Impurity 5 (CAS 1398507-09-9)
- Etravirine (CAS 269055-15-4)
Recommended Standards
- Cyclohexyl 2-Chloro-5-[(2-Fluorobenzoyl)Amino]Benzoate (CAS 178870-05-8)
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- (1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)(piperidin-1-yl)methanone (CAS 303150-18-7)
- Methyl 4-[4-(4-chlorophenyl)piperazino]-3-nitrobenzenecarboxylate (CAS 478246-43-4)
- Betamethasone impurity 73 (CAS 1203841-43-3)
- Plerixafor Impurity 11 (CAS 170161-28-1)
- Nintedanib Impurity 104 (CAS CATO-C4X-1814104)
- 3-((3-Fluoro-4-methylphenyl)amino)-2-(4-(naphthalen-2-yl)thiazol-2-yl)acrylonitrile (CAS 477297-71-5)
- Tert-butyl 3-oxo-4-phenylbutanoate (CAS 66697-03-8)
- 4-[(Benzyloxy)methyl]-4-fluoropiperidine Hydrochloride (CAS 1427173-47-4)
- 5-(2,3-Dihydro-1H-indol-1-yl)-2-(ethylsulfonyl)-phenylamine (CAS 1219976-14-3)
- 5,7-Dimethylbenzofuran-2,3-dione (CAS 31297-28-6)
- (4R,5R)-2-Methyl-α,α,α',α',2-pentaphenyl-1,3-dioxolane-4,5-dimethanol (CAS 109306-21-0)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
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