Etravirine Impurity 2 CAS 1225383-64-1
| CAS No. | 1225383-64-1 |
| Molecular Formula | C20H14ClN5O |
| Molecular Weight | 375.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 375.81 g/mol gives Etravirine Impurity 2 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Etravirine Impurity 2 (CAS 1225383-64-1) is a certified pharmaceutical impurity reference standard with the molecular formula C20H14ClN5O and a molecular weight of 375.81 g/mol.
Etravirine Impurity 2 (C20H14ClN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Etravirine Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H14ClN5O |
| Molecular Weight | 375.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Etravirine Standards
- Etravirine Impurity N2 (CAS 1070377-34-2)
- Etravirine 6-Desamino 5-Chloro Impurity (CAS 269055-05-2)
- Etravirine Impurity 3 (CAS CATO-C4X-13563)
- Etravirine Iimpurity 9 (CAS 269055-19-8)
- Etravirine Impurity N1 (CAS 939431-68-2)
- Etravirine Impurity 4 (CAS CATO-C4X-13564)
- Etravirine Impurity 5 (CAS 1398507-09-9)
- Etravirine (CAS 269055-15-4)
Recommended Standards
- N-(4-chlorophenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide (CAS 338975-83-0)
- Methyl 4-[4-(4-chlorophenyl)piperazino]-3-nitrobenzenecarboxylate (CAS 478246-43-4)
- Cyclohexyl 2-Chloro-5-[(2-Fluorobenzoyl)Amino]Benzoate (CAS 178870-05-8)
- (1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)(piperidin-1-yl)methanone (CAS 303150-18-7)
- Nafamostat Impurity 4 (CAS CATO-C4X-13324)
- Indometacin Impurity 41 (CAS CATO-C4X-147041)
- Picosulfate Impurity N1 (CAS 22945-62-6)
- 1-(4-((2-Aminoethyl)(methyl)amino)piperidin-1-yl)ethanone (CAS 1353974-60-3)
- 6-Chloro-2-(2-methylphenyl)quinoline-4-carbonyl chloride (CAS 1160263-11-5)
- 4-Bromo-2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)aniline (CAS 1249431-17-1)
- 3-Chloro-n-(3-cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)propanamide (CAS 379244-59-4)
- 5'-(3-Aminophenyl)-[1,1':3',1"-terphenyl]-3,3"-diamine (CAS 184650-02-0)
- 4-Dimethylamino-2-oxobut-3-enoic acid ethyl ester (CAS 67751-14-8)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
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