Rotigotine EP Impurity E CAS 2708278-87-7
| CAS No. | 2708278-87-7 |
| Molecular Formula | C19H25NO2S |
| Molecular Weight | 331.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Rotigotine EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 331.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Rotigotine EP Impurity E (CAS 2708278-87-7, C19H25NO2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H25NO2S |
| Molecular Weight | 331.47 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Rotigotine Standards
- rac-Rotigotine-D3 Methyl Ether (CAS 1246820-80-3)
- Rotigotine EP Impurity H (CAS 1148154-91-9)
- rac-Rotigotine-D3 Methyl Ether Amide (CAS 1246814-64-1)
- Rotigotine (CAS 92206-54-7)
- Rotigotine (CAS 99755-59-6)
- Rotigotine Impurity 40 (CAS 102121-00-6)
- Rotigotine EP Impurity A (CAS 112835-48-0)
- Rotigotine Racemate HCl (CAS 102120-99-0)
Recommended Standards
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- N,N-Dibutyl-2-(dibutylphosphoryl)acetamide (CAS 79373-15-2)
- (r)-n-((s)-4-Cyano-1,3-dihydrospiro[indene-2,4'-piperidin]-3-yl)-2-methylpropane-2-sulfinamide (CAS 2377355-64-9)
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